Mastery: AIIMS Practice Test 2026

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Q1Domain Verified

A patient presents with a severe autoimmune disorder characterized by the rapid destruction of pancreatic beta cells, leading to absolute insulin deficiency. Which of the following molecular mechanisms is most likely responsible for the self-attack on beta cells?

Impaired regulatory T cell (Treg) function, failing to suppress autoreactive B cells producing autoantibodies against insulin.

Aberrant expression of MHC class I molecules on beta cells, presenting autoantigens to cytotoxic T lymphocytes (CTLs).

Molecular mimicry between a viral protein and a beta cell autoantigen, triggering cross-reactive T cell responses.

Defective Fas-mediated apoptosis pathway in T helper cells, leading to prolonged activation and cytokine storm.

Q2Domain Verified

In a research setting, a scientist is investigating the role of mitochondrial dysfunction in neurodegenerative diseases. They observe that in affected neurons, there is a significant decrease in the activity of the electron transport chain (ETC) complexes, particularly Complex IV (cytochrome c oxidase), leading to reduced ATP production and accumulation of reactive oxygen species (ROS). Which of the following cellular processes would be MOST severely compromised in these neurons due to this observed mitochondrial dysfunction?

Protein synthesis and post-translational modification in the endoplasmic reticulum.

Calcium homeostasis and synaptic transmission at the neuromuscular junction.

Autophagy-mediated clearance of misfolded proteins and damaged organelles.

DNA repair mechanisms and gene expression regulation in the nucleus.

Q3Domain Verified

A patient undergoing chemotherapy for a solid tumor develops severe mucositis, characterized by painful inflammation and ulceration of the oral mucos

Fibroblasts responsible for extracellular matrix production in the lamina propria.

Resident macrophages of the lamina propria involved in immune surveillance.

Epithelial stem cells in the basal layer of the oral mucosa.

This side effect is primarily due to the chemotherapy agent's action on which of the following cell populations, known for their high turnover rate? A) Endothelial cells lining the blood vessels of the oral submucosa.

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